Nicotine regulates Immunsystem – great for Autoimmun Disease – bad for cancer

During my research into NICOTINE, I looked at its effect on the IMMUNE SYSTEM:

many immune cells have nACh receptors and their activity is therefore strongly regulated via Nicotine
Nicotine modulate the immune system towards “less activity”
this is good for autoimmune CH or inflammatory diseases
This is bad for cancer, especially for glioblastomas and melanomas – but there are studies for every type of cancer

Prof. Köstler Sr. will give a detailed lecture about nicotine and its incredible effect on many diseases at the IGMEDT conference in Vienna on June 14, 2024.

This conference has the coolest and best international speakers we’ve ever had:

PETROS is coming, SIMON YU in person, SABINE HAZAN via zoom, KALCKER via zoom,

and all the Austrian and German celebrities. The conference is also open to interested laypeople

The reason for this article was the immune-deficit findings of a patient

severe immune deficiency

Patient was always healthy before, since the 2nd mRNA he feels that “I’m a construction site”:

severe Zoster– had to get infusions 2 weeks in the hospital,
pneumonia,
constantly sick… .

As we have already found with patients that come with recurrent tumors, there is also a significant weakness in the killer cell system.

The low NK3 in particular bother me a lot because they are the main phalanx against cancer.

In this case, bacteria (NK1) and viruses (NK2) Killercell-deficit is well compensated for by the T4/T8 or T8c/T8s arm of the immune-system

about killer cells

Killer cells

Natural killer cells (NK cells), including NK1 cells, are a type of immune cell that plays an important role primarily in innate immunity. They are particularly effective against:

Virus-infected cells: NK cells recognize and destroy cells infected with various viruses without the need for prior sensitization. They detect stress signals or changes on the surface of infected cells.

Tumor cells: NK cells can also recognize and eliminate many types of tumor cells. It does this by detecting abnormal or missing MHC (Major Histocompatibility Complex) class I molecules that are normally presented on healthy cells. Tumor cells that lose or change these molecules are recognized as targets by NK cells.

Nicotine as a “cure” for PostCovid complaints?

Because Dr. Bryan Ardis argues for NICOTINE as the main remedy against SPIKE damage, I have now looked at the effect of NICOTINE on the immune system.

In any case, subsequent study research shows a completely differentiated picture, with NICOTINE being BAD for those with weakened immune systems!

The following article about Bryan Ardis is very, very interesting, especially the video is fantastic

Loss of Smell after Covid – Nicotine might help

Nicotine is probably great for autoimmune diseases and inflammation

Rheumatism / PCP

2011 study shows that nicotine causes a weakening of the perverted autoimmune TH17 immunity, however in mice and there we know that the killer cells do not have nACh receptors, so perhaps they cannot be transferred 1:1 to humans?

Encephalitis – Multiple Sclerosis – ME/CFS

Nicotinic Attenuation of Central Nervous System Inflammation
and Autoimmunity

Study 2009 | FulltextPDF shows noticeable reduction in brain inflammation caused by nicotine: translated here from the study:

…. Nicotine is probably helpful …. for stroke, Alzheimer’s disease, Parkinson’s disease, epilepsy and possibly other brain diseases (19, 20).

To determine the influence of nicotine exposure on a CNS autoimmune response, we used the experimental mouse model of autoimmune encephalomyelitis (EAE) of MS. Immunization of C57BL/6 (B6) mice with the myelin oligodendrocyte glycoprotein (MOG) peptide activates T cells in the periphery and subsequently produces marked cellular infiltration and demyelination in the periphery CNSas well as a monophasic neurological deficiency, resembling a form of MS in humans, acute disseminated encephalomyelitis (21). We found that nicotine exposure delays and dramatically attenuates CNS inflammation and the autoimmune response to myelin Ags, suggesting several novel mechanisms of neuroimmune interaction.

Nature review from 2009 on nicotine in neurological diseases

https://www.nature.com/articles/aps200967.pdf

….there is increasing evidence that smokers are less likely to suffer from some inflammatory and neurodegenerative diseases.

Nicotine is the main immunosuppressive component of cigarette smoke, inhibiting both the innate and adaptive immune responses. In contrast to cigarette smoke, nicotine is not yet considered a carcinogen and may actually have therapeutic potential as a neuroprotective and anti-inflammatory agent. This review provides a summary of the effects of nicotine on the immune system and its (nicotine) influences various neurological diseases.

Therapy of autoimmune hepatitis with nicotine-pretreated stem cells

Benefits of conditioned medium of nicotine-pulsed mesenchymal stem cells in experimental autoimmune hepatitis

The study from 2024 shows that bone marrow stem cells that are pre-exposed to nicotine can significantly improve “autoimmune hepatitis”, whereby the immune-modulating anti-inflammatory effect of nicotine is discussed.

it seems to be different with CANCER

Once again, the immunomodulatory role of nicotine is confirmed in the sense of an inhibition of killer cell activity

Nicotine is bad for glioblastoma

contrary to the statement of Dr. Ardis, who is in hisInterview claims that glioblastomas disappeared in mice with nicotine in 2 weeks, the study situation is diametrically opposite.

Nicotine accelerates and worsens the progression of glioblastomas, here for example a review from 2019

24,000 studies with nicotine in glioblastoma, the first 8 out of 10 show a worsening of the prognosis due to nicotine, so I wouldn’t give it!

some study examples

1 million study entries in Scholar for the search term NICOTINE x CANCER

So enough material to do differentiated research

Killer cells inhibited by nicotine

The study suggests that nicotine has an anti-inflammatory effect via activation of the α7 nAChR (nicotinic acetylcholine receptor) on human NK cells (natural killer cells).

This happens through several mechanisms:

Reduction of IFN-γ production,
Decrease in cellular cytotoxicity
Inhibition of the activation/maturation of dendritic cells.

These results show that nicotine activation of the α7 nAChR in NK cells can modulate pro-inflammatory responses and potentially have an anti-inflammatory effect.

Metastasis accelerated by killer cell inhibition

The study shows thatnicotine negatively affects the function of NK cells (natural killer cells).

Nicotine reduces activating signals and immune effector molecules on NK cells, resulting in reduced proliferation, cytokine production, and cytolytic activity. strong> towards target cells.

This is primarily mediated by the nAChR β2 subunit.

Nicotine-induced suppression of NK cell functions results in increased tumor burden in mouse lungs, especially in the context of melanoma metastases.

This shows the crucial role of NK cells in recognizing and combating tumor cells.

Nicotine impairs the anti-tumor immunity of NK cells, which facilitates the spread of early-stage melanoma in particular. These findings suggest that restoring NK cell function impaired by nicotine could be a potential strategy to boost the immune system’s ability to prevent tumor spread.

Inhibiting the effect of nicotine is cancer treatment

A 2011 2011 review | FulltextPDF – where you can see that if you block the nAChR with antagonists (i.e. actually opponents of nicotine), there are better results in cancer.

if you have such an immune deficiency post-Covid?

regarding the patient above: this is how I went from being a vaccination supporter to a vaccination critic .....

Yes, there is, as described above. From Covid itself but also from the vaccination. Thankfully not for everyone, but always.

Even if the official media dismisses something like this as a hoax and right-wing radical and the medical association has reprimanded me several times, unfortunately I see these vaccination side effects in my practice, me too myself – my wife and my mother were also able to experience it.

So I became a clear supporter of vaccination from the practice to a critical vaccinator, i.e. I still vaccinated but only under “reservation” upon urgent request.

where can you get such an immune measurement

With every doctor with training in micro-immunotherapy, including us in Vöcklabruck.

Now I’m pretty fully booked myself – but the nurses do this kind of laboratory measurement and they can have it in our office at any time without any significant waiting time (Mon-Tues only in the mornings). The secretary takes them in, the nurse takes the blood and they take it directly to the post office themselves because express shipping is required by noon.

For patients with regional health insurance funds, the health insurance company pays for almost everything, only the TReg cells are stuck with a deductible of around 50 euros

For the evaluation of the findings (via email) I charge 30, – unless it takes longer than 10 minutes, then correspondingly more.

What to do if the killer cells are almost gone?

With the cancer rate currently rising, I can’t keep a program like this to myself, so here’s how to proceed. In any case, you need a doctor who has to prescribe the preparations.

our best natural-killer cell stimulation protocol