Evidence from the latest research offers a glimmer of hope in the fight against this devastating disease – a recommended article for colleagues!
Summary of this article
-
- Parkinson as a synuclein-o-pathy is cell death triggered by “dirt proteins” (synuclein precipitates or amyloids) that can block
their own autophagic degradation
- But with spermidine you can save it, probably also with therapeutic fasting!
- with Trittico you can block the death of the affected cells because it is currently the only agent that can stop the unfolding protein response – cell death.
with this we would at least have brought the evil Parkinson’s process under control! But despite this, 80% of the cells have already been irreversibly damaged.
- With Filgrastim as a stem cell inducer, we could possibly even bring about a real improvement through the “regrowth” of dopaminergic neurons, or at least that’s what the animal studies suggest. Filgrastim has been used billions of times worldwide and is approved for – other diseases.
Today there were two Parkinson’s patients here again – I pray that I am spared something like that, better to do some research now!
When you get Parkinson’s symptoms, it’s already too late
Unfortunately – when the symptoms start, 80% of the dopaminergic striatal neurons are already damaged. The remaining neurons can no longer compensate for the loss and the movement problems start.
Diagnosis is confirmed with a DOPA PET SCAN. If the DOPA in the brain is not sufficiently absorbed in the corresponding region, the neurons are missing and the diagnosis is confirmed.
If something in the body is broken, it can usually no longer be repaired.
We can often compensate for the MINUS symptoms (difficulty getting started, staggering, movement blockages…..) quite well for a limited time by administering L-DOPA (precursors, analogues,…..), but this is often not enough.
Recently, “atypical Parkinson’s” has also become more common – unfortunately, it does not respond to L-DOPA.
For the PLUS symptoms: tremors and chorea (after taking dopamine agonists), deep brain stem stimulation and, more recently, focused ultrasound ablation are options; this is not yet routine therapy, but will be soon. You can read about this in Tony Robbins’ new book “Life Force”
Cause of Parkinson’s
around 5% are genetic due to around 90 different mutations that have been discovered.
Connection with constipation, just like not smoking – i.e. nicotine protects in some way. (Lancet Review 2021)
Molecular: Apoptosis of neurons due to deposits of aberrant (dirt) proteins “alpha-synuclein” which produce “protofibrils” and lead to the death of neurons due to “dirt fiber substances” – also called “synucleinopathy“.
The term has now been expanded to include a whole group of diseases, the so-called SYNUCLEINOPATHIES:
- Parkinson
- Lewis Body Dementia
- Multi-System Atrophy
It has been found that these protofibrils are deposited preferentially in peripheral neurons that belong to the autonomic (sympathetic) nervous system, so that constipation is not the cause but an early symptom of Parkinson’s, because the necessary intestinal nerves do not work correctly due to the protofibrils. (Review 2019)
Here is the cause of cell death in brief
explained in more detail below
[1] Neuromelanin is a “polymer” – like plastic, the polymer consists of oxidized dopamine – which in turn indicates oxidative stress.
If metals and iron [2] are deposited in these neurons at the same time, these metals combine with the dye polymer neuromelanin. This turns the iron into a “super catalyst” that converts any oxygen that flies past into ROX (free radicals = oxidative stress) via the Fenton reaction [3]
Too much iron in the blood is therefore bad and we therefore perform bloodletting when the ferritin level is as low as 180-200. Dental amalgam is also bad because the mercury evaporates from there and drifts directly through the oral mucosa into the brain; most Parkinson’s patients had amalgam or gold fillings.
a-synuclein aggregates
This oxidative stress changes a local structural protein called a-SYNUCLEIN so that it clumps together to form hard-to-dissolve deposits. Like amphibians in the corners of the floor in an apartment [5].
This dirt/amphibian a-SYNUCLEIN has the unpleasant property of resisting cleaning and “vacuuming” away. In the cell there is a cleaning mechanism called AUTOPHAGY which removes and dissolves oxidized / old / broken structures [6], which are absorbed into small bubbles and dissolved there.
The large synuclein aggregates [5], however, make this vacuum cleaner “autophagy” useless, blocking the vacuum cleaner as if it were made of long Mikado sticks which clog the vacuum cleaner’s suction hose.
If there is a certain amount of synuclein in the cell, a safety instance “UPR” [7] decides that this “dirty” nerve cell should die.
Because: a “dirty cell” could become cancerous, that must be prevented at all costs, so it is better if the cell dies [8].
Cause of synucleinopathies in more detail
Now that we know that there are certain dirty proteins, where do they come from? Of course they are misfolded and genetics play a role – but why? People functioned perfectly for many decades.
When I ask ChatGPT about the reasons for the accumulation of alpha-synuclein, I find the following clues in addition to the usual banalities:
Aging: As we age, the ability of cells to efficiently remove damaged or misfolded proteins decreases. This can lead to the accumulation of synuclein fibrils and other protein aggregates.
Disturbances in the cellular waste disposal system: Defects in the cellular systems responsible for removing damaged or misfolded proteins, such as proteasomes and autophagy, can lead to the accumulation of synuclein fibrils
OK – that’s helpful! So let’s look in the research database for “autophagy and synuclein”
Disruption of autophagy by α-synuclein
If you now go to the study database, you can see that the evil α-synuclein can directly block the breakdown of dirty proteins, the so-called autophagy (2010 study).
OK – that means the aberrant protein blocks the process of cell cleaning – these fibrils seriously prevent the cell from getting rid of them!!
But: we know of a natural substance that can turn up AUTOPHAGY: spermidine.
Is this drug able to break through the blockage of autophagy caused by the protofibrils?
In fact: spermidine has many studies with positive outcomes
well, 1200 studies aren’t that many but nevertheless: the studies are clear:
in animal models and cell cultures, spermidine can reduce or even eliminate the effects of synucleinopathies!
It becomes much clearer when we search for studies on Spermidine and Parkinson: 11,000 studies – YES – Spermidine helps but it will never be used because it is a natural substance and therefore less interesting for the pharmaceutical lobby and professional associations and guidelines”.
Perhaps someone with university access can download the entire review and send it to me: https://www.sciencedirect.com/science/article/abs/pii/S0143417920301013
Death throes of dirty cells due to UPR system
Neurodegeneration reminds me strikingly of Alzheimer’s, where it is the toxic phosphorylated TAU proteins that accumulate and force the affected NEURONS into apoptosis.
We have understood the mechanism behind this, the UNFOLDING PROTEIN RESPONSE SYSTEM (UPR):
When “dirt” accumulates in cells, these cells try to get the misfolded proteins back into the right place with the help of heat shock proteins. But if this fails, the cells “die for safety”it they do not become a burden on the organism.
This dying is triggered by this UPR and a sleeping pill called Trittico (Tradozone) can prevent this (Study 2018)
I discovered this years ago and published it here and have been using Trittico successfully in my practice for years to treat Alzheimer’s, you don’t even need a lot of it and it is a “standard sleeping pill” that every general practitioner prescribes 20 times a morning anyway.
So: with spermidine we can reactivate the dissolution of the fibrils (because the fibrils block their own degradation), we can prevent the death of the affected cells with trazodone – this has already been clinically proven in my practice and in studies (EBML4) –
but we still don’t know why the alpha-synuclein clumps together in certain cases and how I can prevent this – but we have now at least brought the process to a standstill with the 2 agents.
Nevertheless, 80% of the neurons are broken and that is why we have the miserable Parkinson’s – what can we do about it?
Intestinal problems
a-synuclein aggregates also clog the intestinal nerves (vagus) so that they no longer work as well. Because these nerves are particularly long, these disorders often become apparent much earlier, which is why Parkinson’s patients usually have constipation and flatulence / a bloated stomach.
This also leads to a change in the intestinal flora and experts are discussing whether this does not produce additional stress, which worsens the disease?
In any case, it is clear that most metals – especially mercury – are excreted via the intestines and – mercury in particular has an “enterohepatic circulation”, i.e. the methyl mercury diffuses from the intestines back into the blood and into the intestinal nerves and is transported up to the brain via these nerves.
This is why improving intestinal transit and administering “binding agents” is very important for Parkinson’s disease, the stool should under no circumstances sit around in the intestines for longer than 12 hours and “re-poison” the brain.
SHARE plums have proven to be very effective here, definitely take a piece every day! There are over 2000 studies that show positive effects here.
- 🌿 TRADITIONELLE FERMENTATION: Unsere Share Original fermentierte Pflaume jap. Aprikose durchläuft einen...
Stool transplantation
should also be mentioned in this context, it seems to be highly effective, but will never be successful because it is far too cheap, and will therefore be opposed by the industry and the associated professional associations.
Experimental therapy “fecal transplantation”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458210/
Abstract of the study translated into German:
Imbalances in gut microbiology influence the progression of neurodegenerative diseases such as Parkinson’s disease (PD). Fecal stool transplantation (FMT) is currently being investigated as a potential therapy for Parkinson’s. The aim of this study was to evaluate the efficacy and safety of FMT in Parkinson’s.
Fifteen PD patients were included, 10 of them received FMT via colonoscopy (colonic FMT group) and 5 received FMT via a nasal-jejunal tube (nasointestinal FMT group).
The scores of PSQI, HAMD, HAMA, PDQ-39, NMSQ and UPDRS-III decreased significantly after FMT treatment (all P < .05).
The colonic FMT group showed significant improvement and longer maintenance of efficacy compared with nasointestinal FMT. Two patients achieved satisfactory results lasting more than 24 months.
However, the nasointestinal FMT group had no significant therapeutic effect, although the UPDRS-III score was slightly reduced. There was no patient who was satisfied with nasointestinal FMT for more than 3 months.
Among 15 PD patients, there were 5 cases of adverse events (AEs), including diarrhea (2 cases), abdominal pain (2 cases) and flatulence (1 case). These adverse events were mild and self-limiting.
We conclude that FMT can relieve motor and non-motor symptoms in Parkinson’s disease with acceptable safety. Compared to nasointestinal FMT, colonic FMT seems to be better and preferable.
In total, there are 16,000 studies on the topic of stool transplantation and Parkinson’s disease
see belowThe book by Dr. Sabine Hazan, which is cited above, shows the very latest research, some of which has fantastic results. I have cited it several times on my website (1, 2) with YouTube videos.
The book is also available as Audible and Kindle
Stem cell course in Brussels 2020
I was in Brussels in 2020 to learn stem cell therapy. We personally performed bone marrow punctures and injected the KnM stem cells back into the brains of Parkinson’s patients using a lumbar puncture.
In the article here I even made a YouTube video about the course, where you can see how we inject the stem cells into a Parkinson’s patient.
If this is already being used in practice, it means that the bone marrow stem cells can also regenerate the brain.
One naturally asks oneself: are there enough stem cells in the bone marrow that can differentiate into nerve cells?
In any case, there are enough mesenchymal stem cells in there, I think I remember that 7-10% of the stem cells from the bone marrow are mesenchymal.
Stem cells in the brain – yes, that helps with Parkinson’s
Studies show that mesenchymal bone marrow stem cells (which have been injected into the brain) can lead to an 30% improvement in Parkinson’s symptoms and that patients need significantly less medication overall (e.g. 2010).
Whether this is a direct replacement of damaged nerve cells with these KnM stem cells or the stem cells simply release exosomes and these exosomes then stimulate the brain’s own stem cells is irrelevant, the clinical studies and many preclinical studies confirm the effect.
Again: stem cells can actually improve Parkinson’s
Bone marrow stem cells – complex procedure
After the stem cell course, I ultimately decided NOT to carry out bone marrow stem cell surgery because the effort involved in surgery etc. would have been too great for me.
But we use bone marrow stem cells every day!!!!
During the so-called stem cell transplant, e.g. in leukemia therapy, the DONOR is injected with a biological called Filgrastim, which stimulates his bone marrow incredibly strongly.
After several of these injections, the stem cells that are now released are extracted from the donor’s blood and transfused into the recipient, where they build up a new bone marrow and immune system.
Actually, this is the same process as the KnM puncture to extract stem cells from the KnM??!!
We doctors work with this biological every day – when working with cancer patients and therefore know all the side effects that are foreseeable or minor!
I have been working with this preparation “off-label” for autologous stem cell stimulation for 1 year and have also used it to regenerate my heart after it had been pretty damaged by a gene therapy that was common at the time.
Filgrastim as a bone marrow stem cell stimulant
could we also use this stem cell stimulant directly for Parkinson’s regeneration? We would thus be spared the complex KnM puncture and the lumbar injection of the stem cells, which may have side effects?!
Filgrastim can actually ease Parkinson’s disease
only 1200 studies – that’s not really a lot – but the first ones are already very promising.
I’m really happy about that: Dr. Maria Gonzalez from Monterrey published this study with partially successful stem cell transplantation for ALS – she was our trainer in Brussels!
In Stiff Person Disease great response to autologous stem cell transplantation (2020)
I haven’t seen any clinical studies with pure filgrastim administration for neurodegenerative diseases, just filgrastim –> harvesting stem cells –> then injecting these harvested stem cells.
BUT: in animal experiments, experimental Parkinson’s disease can be “saved” with pure filgrastim administration (2011 study)
i.e. with filgrastim stimulation of stem cells, one could possibly improve the situation int advanced Parkinson’s disease, and in animal models it can even significantly improve early Parkinson’s disease.
Summary of this article
- Parkinson’s disease as synuleinopathy is cell death triggered by dirt proteins that block their own degradation through autophagy
- But with spermidine you can save it, and probably with therapeutic fasting!
- with Trittico you can block the death of the affected cells because it is currently the only agent that can stop the unfolding protein response – cell death.
with this we would at least have brought the evil Parkinson’s process under control! But despite this, 80% of the cells have already been irreversibly damaged
- with filgrastim as a stem cell inducer, we could possibly even bring about a real improvement through the “regrowth” of dopaminergic neurons, or at least that’s what the animal studies suggest. Filgrastim has been used billions of times worldwide and is approved for – other diseases.
what does the future hold?
Osman Kibar said in the Vatican in 2018: there is no tissue that they have not been able to completely regenerate, they have shown that they have regenerated a completely degenerated Alzheimer’s brain as well as a completely scarred pulmonary fibrosis and much more.
something else – p-Stim
I saw a video by Dr. Petros Kattou in Cyprus at the Brain Bio Center there. He works with the Austrian p-Stim and showed me a patient who had been in a wheelchair for 2 years because of Parkinson’s and can walk again after a few months of treatment with p-Stim and the Platoscience Brain Stimulator.
Spermidine dosage
just briefly, don’t have time to research, ChatGPT gives me the following answer:
Based on information up to September 2021, there are studies that have investigated the effect of spermidine on autophagy in the brain. The dosages in these studies can vary, and there is no uniform dosage recommendation. However, here are some examples of dosages used in some of these studies:
- In a study in mice to investigate the effects of spermidine on autophagy in the brain, spermidine was administered to the animals intraperitoneally at a dosage of 3 mg/kg body weight.
- Another study in rats to investigate the effects of spermidine on autophagy in the brain used a dosage of 10 mg/kg body weight administered to the animals orally.
It is important to note that spermidine dosage may vary depending on the animal model, method of administration, and specific objective of the study. In addition, dosages for human studies should always be determined with safety considerations and individual patient factors in mind.
Summary Treatments
from this article here
- Spermidine 12mg / day
- Trittico 75mg retard in the evening
- Filgrastim – e.g. every 12 weeks
what else could be interesting?
- Lithium to make brain cells grow back
- Pregnenolone 50mg or progesterone 100mg (oral) to regenerate the brain
- naturally VitD + K2
- optimize intestinal bacteria – there is a strong connection here, people with Parkinson’s have TOO MUCH Lactobacillus and Bifidus and too little Lachnospiraceae
- homeopathic stem cell stimulation with Substantia nigra D6 twice daily
- Low Dose Naltrexone (e.g. study here, or entry on the ALS Website)
- CBD clearly has an effect (Study) –> where to buy: Lukovitaal
- Brain infections must of course be treated (Lyme disease, HERV, HHV6, Borna …)
If any of the readers have any relevant information: please leave a comment below, thank you!
Now I’m going to go smoke a cigarette to do something about Parkinson’s!
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