Stress is one of the main factors for tumor growth – and – NEW: inhibits checkpoint inhibitor therapy
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Stress = adrenaline = noradrenaline causes cancer to explode
“Miracle Treatment” say scientists about the amazing results of stress blockers in ovarian cancer:
Triple increase in survival rate compared to chemo (Study 2016) –
Stress = adrenaline = noradrenaline causes checkpoints to lose their effect
Checkpoint (inhibitors) are the most modern therapeutic approach in oncology: they influence the immune system in such a way that it is no longer confused by cancer and finally fights it.
Cancer enslaves TRegs, the master cells of immune suppression
The enslaved Tregs produce immunosuppressive cytokines for the cancer, such as TGF-ß, IL10 ….. – this neutralizes killer cells directed against the cancer, they fall asleep.
Of course, we integrative oncology doctors use TReg inhibitors – such as an ancient stomach remedy repurposed – to give the immune system a helping hand.
Stress activates the TRegs and inhibits checkpoints
This new milestone study from August 2017 shows a mouse model in which the stress signals were interrupted in three different ways:
- physiologically via temperature changes in the environment
- pharmacologically: via the use of beta-blockers
- genetically: with ß-receptor knockout mice
All 3 models show the same study results: the more stress signals in the mouse, the faster the cancer grows and the more TRegs and the less effect from checkpoint inhibitors or vice versa:
the fewer stress signals, the slower Cancer growth and spread and the fewer TRegs and the more effect through checkpoint inhibitors.
Basically a further confirmation of now almost 2000 studies on the subject of beta blockers & cancer, many of which are also clinical studies in humans.
The new thing here is the expansion of the stress-cancer axis to PD1 or checkpoint inhibitors.
- Stress undermines tumor therapies
- Stress causes tumors to metastasize
- Stress really heats up tumors
- Beta blockers are essential for checkpoint inhibitor therapy to adjuvant the effect
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