Senescence is the biological feedback mechanism by which nature ensures that “organisms that have reached their limits” actually die off quickly. To age healthily, this mechanism must be counteracted. More and more studies demonstrate this important preventive health factor.
When we “age,” we should actually be “wiped out” – says nature.
That’s what nature means: when an animal or plant declines in any way or has passed its prime, it should no longer be a burden on the community geared for optimal survival as a predator, but rather be quickly eliminated.
There are feedback mechanisms in the body for this: “Do you want to live forever?”
Cells in the body that have reached their biological limit do not die but rather “senesce.”
These “SENIORS” are called senescent cells, and just like in real life, they require “extra attention”: they constantly send emergency signals to their surroundings by releasing senescent exosomes.
Senescent inflammasomes
These exosomes are also called inflammasomes. They are full of inflammatory factors and TAU protein (which then triggers Alzheimer’s disease in the brain, for example), as well as TNF-alpha and IL-6, which trigger a high inflammatory status and immune deficiency in the “old,” and also promote cancer – without senescence, it’s almost impossible to get cancer!
Here, from a great review, is a comparison of “old” and “young” exosomes.
by Rocío Mato-Basalo, Life Volume 12 Issue 4 10.3390/life12040546
the top graphic shows the senescent exosomes, full of inflammatory and disease-promoting factors.
in the bottom graphic, in comparison, are the exosomes of young cells: full of vitalizing factors. Clicking on the graphic opens the original review from May 2022.
Exosomes are very powerful modulators in the body
An exosome is almost like a virus; it can fuse with other cells and “imprint” information on them. The exosomes from old, senescent cells poison other cells and switch them to “paracrine senescence.”
just like an rotten apple can ruin the whole basket – senescent cells send healthy cells into senescence –> a positiv feedback loop toward death.
Exosomes from fresh embryonic stem cells are the most powerful revitalizing factor
Stem cell exosome therapy as a fountain of youth and regeneration factor
If I administer these “young exosomes” to elderly people as “exosome therapy,” studies show an outstanding improvement in healing, inhibition of inflammation, and cure of diseases.
–> I have seen numerous cases of fantastic exosome therapy successes during my stem cell training in Brussels, read my article about it (translated via google translation)
of course the Top-Shots use this technology
Top soccer players in the European league receive up to six exosome injections after a game (which they collect by private plane from Mexico) and experience unprecedented regeneration.
Exosome therapy in the context of COVID-19 infections
Here in the graphic below (from the same review) are the results of a COVID-19 study:
Administration of (mesenchymal) stem cell exosomes (MSCs) to elderly people: great success in COVID-19, while the “old” die without “young exosome support.”
Action Mechanisms of Small Extracellular Vesicles in Inflammaging, Life 2022, 12(4), 546; https://doi.org/10.3390/life12040546
Very bad: senescent cells are “contagious”
(c) journal mol. med. & Wendy OostThese senescent exosomes lead to an EXPANSION of senescence in the surrounding area, so that suddenly more and more cells become aging and dysfunctional.
Stem-Cell repair is blocked
At the same time, the “inflammatory exosomes” block the stem cells present throughout the tissue, thereby largely preventing regeneration!
This is the mechanism by which humans suddenly “age” very quickly, often within 1-2 years, from a fairly vital state to a frail, painful, and pro-inflammatory state.
Feedback mechanism to “let the old die quickly”
From nature’s perspective, it is important and necessary to eliminate those individuals who have reached their expiration date relatively quickly in order to avoid weakening the surviving gene pool with “weak/old members.”
This cellular contagion of senescence—the spread and rapid aging of cells, the immune deficiency and the pro-inflammatory state, as well as the death of the brain due to TAU protein deposits—all of this makes evolutionary sense.
For us humans, who have freed ourselves culturally, scientifically, and industrially from the “clutches of nature” and now no longer eliminate existing genetic weaknesses through outcrossing and breeding, but rather cure them through CRISPER/CAS or other gene therapies, these “expiration date reached” mechanisms are annoying.
Because they don’t necessarily mean that we’ll quickly “die” as planned from an air infection caused by a cold draft or a fall after dizziness—great conventional medicine largely prevents this—but rather that we’ll simply suffer a lot until we die and be able to do very little “vital activity.”
Senolysis, one of the most important anti-aging mechanisms
In future articles, I will present current studies and their results.
Also the result of my own Senolysis treatment, which shot me back from 69 to 51 years of “biological age” and regenerated my diseased heart. Lenna became 12 years younger biologically.
In the meantime, enjoy the following two exciting articles I wrote on the topic (leave them here in german so you would recognize the pictures, please access them via the following Google translation link)
And what’s in the PIPELINE—actually true, albeit so unbelievable—is described in this article:
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