this is the detailed treatment protocol for doctors, I have the explanations and background on the page “Nadir protocol for amyotrophic lateral sclerosis“
ALS – Nadir protocol modified according to Retzek: Medication
THE PROTOCOL
- Imurek 3 x 1 tablet / day with food
- Dexamethasone slowly reduce the dose according to the plan
- Nebido Testosterone – 1 milliliter i.m. once a month
- Mucospas tablets – 3 x / day (only start after the first month)
the individual medications are described
1) Imurek – immunosuppressant
this is given to patients with joint rheumatism, intestinal inflammation, skin or heart muscle inflammation or even organ transplants. It is a relatively “heavy” medication and you have to have a blood test done very regularly (actually weekly) at the beginning to check that you are tolerating it.
Laboratory checks: blood count, platelets (weekly), liver values (monthly)
1 x 3 tablets, with food (I’ve seen different information in the package inserts).
After a few months, I plan to try to reduce the dose.
2) Dexamethasone – Cortisone
Start with 8 mg and reduce to 4 mg over the course of 12 days.
From 4 mg, you can hardly expect any side effects (stomach). At 8 mg, it can affect your stomach, and you may need a stomach tablet or alkaline powder for a few days – call or ask your doctor at any time.
You continue to reduce the cortisone slowly by reducing it by ½ mg every month.
You “make” the desired concentration by combining original tablets and pharmacy-filled capsules, which we fill from the tablets so that dosage is easier.
If you respond, there is an improvement of around 10% in the first week. After that, it stays stable, no more deterioration, tends to be more mini-improvements, but what is pretty much gone stays that way – we need stem cells here. I can now confirm this based on 3 cases.
If the symptoms get worse again when reducing Dexa, please go back to the concentration that worked before and stay on it for a longer period of time before trying to reduce it again.
Everything that NADIR and Dr. H Schmidt describe is what I have experienced with my cases so far.
The table below shows how to take it, for example in the first month you take 3.5mg dexamethasone from day 12 to day 30, this dose is made up of: ½ tablet 4mg dexamethasone + 1mg capsule + 0.5mg capsule
| TAG . | Month . | mg Dexa . | Tbl 4mg Dexa – | Kps 1mg . | Kps 0.5mg |
| 1-4 | 8 | 2 | |||
| 5-8 | 6 | 1.5 | |||
| 9-11 | 4 | 1 | |||
| 12 – 30 | 1 | 3.5 | ½ | 1 | 1 |
| 31 – 46 | 2 | 3 | ½ | 1 | |
| 47 – 60 | 2.5 | ½ | 1 | ||
| 61 – 90 | 3 | 2 | ½ | ||
| 91 – 120 | 4 | 1.5 | 1 | 1 | |
| 121 – 180 | 5 | 1 | 1 | ||
| 181 – ….. | 6 | 0.5 | 1 |
3) Testosterone
Testosterone has a muscle-regenerating and even muscle-building effect on men and women, progesterone has a brain-regenerating effect on women and men.
In Austria we only have Nebibo, which corresponds to a 3-month injection.
At the moment we are doing it in such a way that we administer ¼ of the Nebibo injection every month – that is 1ml i.m. and then give 250mg testosterone undecanoate every month.
There is also the transdermal variant with 50mg Testogel per day, but this is not covered by health insurance.
Attention: If you are very overweight or regularly drink alcohol, you must take Letrozole (e.g. twice a week) in addition to testosterone! Please check your blood pressure from time to time, as testosterone can cause blood pressure to rise. Blood values are checked regularly anyway because of the IMUREK.
For women, ½ a sachet of the 25mg Testogel or ¼ of the 50mg.
Testosterone does not have to be present right from the start, the nadir also only occurs after monthstestosterone was introduced.
Side effects: prostate enlargement (prevented by letrozole, usually only in obese people or alcohol because testosterone is then converted into estrogen), increased blood pressure, blood thickening. If this occurs, letrozole is taken to combat the side effects on the prostate.
4) Clenbuterol – Mucospas
3 x daily, in an Italian study after one year, showed a 30% muscle improvement compared to non-clenbuterol patients. The drug is called Mucospas.
Laboratory tests
Blood pressure: initially daily, then weekly
Initial blood test:
“Standard laboratory”: BB, Diff, CK, LDH, gGT, GOT, GPT, Bili (di/ind), HS, Chol, HDL, LDL, TGZ, Ferritin, HbA1c, Lipase, Amylase, CRP, ANA, AMA, ACE, Progesterone, Estrogen, Testosterone, FSH, LH, CMV, EBV, Toxoplasma IgG, Bartonella IgG, Babesia IgG, Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma, TPHA, Lyme disease IgG including Western blot, Ascaris, Filiaria, Toxocara, Lymphocyte subtyping including TREGS and MIT graphics
“Special laboratory Prof. Greilberger, Graz”: Retzek panel including Rantes
Laboratory tests for therapy
- Blood (1) – weekly at the beginning: especially platelets (Imurek) – after 4 weeks only monthly
- Blood (2) – monthly liver values, kidney values (+ blood1)
- Blood (3) – every 3 months: SHGB / testosterone / estrogen / progesterone / dehydrotestosterone / PSA (+ blood2+1)
- Measure pulse / blood pressure daily and write down
Dietary supplements
Retzek: CBD is particularly important, at least 10 drops of 10% / day in the evening
Here are the “standard dosages” of a good orthomolecular supply:
- Magnesium at least 300mg as “multi-salt” – e.g. fullnesium or seven salt,
- VitD at least 10,000IE + K2 200µg,
- MultiB100 every other day,
- Q10 200mg / day.
- Calcium not extra, is sufficiently “produced” by VitD
- Progesterone (Utrogestan) in the evening 1 Capsule
I recommend a diet rich in fats and proteins
Retzek: Paleo diet, especially “autoimmune paleo” to minimize the autoimmune component of amyotrophic lateral sclerosis. In this sense, I would also use LDN (low dose naltrexone) as well.
Exercise moderately without putting strain on your muscles.
This is very important. When the motor nerves are subjected to greater strain, a lot of nitrostress and peroxide are created in the nerves, which forces the nerves to degenerate. So with exertion, you break down much faster.
Prescriptions – everything would have to be paid for by the health insurance company
- Imurek 50mg OP1/50 – 3 x 1 (2 OPs/month) 31,-
- Dexamethasone 4mg Tbl OP2/30 24,-
- or Fortecortin 4mg Tbl OP1/100 (30) 131,- (30,-)
- either Testogel 50mg OP1/30 (1 OP/mo) 80,-
for women: 25mg OP1/30 (1 OP for 2 months) - or Nebido 1000mg / 4ml injection solution OP1 164,-
- Mucospas Tbl OP1/20 3 x 1 (1 OP per week) 6,-
- Utrogestan 100 Kps OP2 0 0 2 (2 OP per month) 11,-
- Dexamethasone gastro-resistant capsules 1mg OP1 / 125
- Dexamethasone gastro-resistant capsules 0.5mg OP1 / 250
Please report back at least every 2 weeks, at least by email, carry out the laboratory tests, send every laboratory test, write down blood pressure, fill in the progress parameter score!
Disclaimer
The information provided in this article is for general informational purposes only for my collegues and is not intended to replace professional medical advice, diagnosis, or treatment from a qualified healthcare provider. The described therapeutic approaches, particularly concerning ALS, are based on individual case reports and experimental applications that have not been validated through large-scale clinical studies.
Any medical treatment should always be undertaken in consultation with a qualified healthcare professional. The author assumes no responsibility for any damage resulting from the application or misuse of the information presented in this article. The responsibility for health-related decisions lies solely with the reader.
In case of doubt, please consult a physician or another qualified healthcare professional before making changes to existing treatment plans or trying new therapeutic approaches.
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