Multiple Sclerosis – what can we actually do using Neuromodulation

a patient writes me an email to talk to me on Zoom or Whatsapp because of his progressive MS that confines him to the walker now.

read here my answer to get deeper insights in our office treatment modalities for MS

Email-Answer to Patient who wants a Zoom call for SPMS

Hi Raiko,

at present I am still able to answer a mail, I do this mail extensively to put it on the website to answer others as well who want to learn more about it.

Petros – who basically “invented” this mode of treatment – has now a million of FB followers and is overwhelmed with 25.000 applications per month and has a waiting time of about 5 years now.

I am proud to be the first doctor that Petros trained and the one with the most trainings having been at almost all of the trainings since then. Now we are also the first office outside Cyprus who is using TPS.

You want to talk to me on Zoom or Whatsapp:

Look, there is no other way than to come to us, we cannot support via Zoom or Whatsapp. Now I do not really withstrain to talk to you on Zoom or whatever but why and whatfor beside confirming that it can and will probably work.

We do that an a daily bases. Initially we cried with every patient, meanwhile its “every day’s” issue and we expect it.

I am an old physician, having seen a lot and done many trainings, I am actually short befor retirement and I can confirm you that this is the most effective treatment for MS and the only one that helps on progressive MS.

We do in the meanwhile only Neuromodulation as most effectiv treatment for MS, I gave up on Coimbra for progressive MS – does not work,

and we do it not by doing it on you

but by teaching you to apply it.

Its actually a home treatment.

Physician is necessary to analyze positions and evaluate your status.

If you have such a quick aggravation as you write you need a Vagus as well as a tDCS device that you use 5x per week, probably even at several position (2-3 positions) per day (!) – so not for the lazy ones.

It can be used though through pretty every task beside swimming: during work, household, rest, sleep, …..

This devices basically will stop the inflammation process and will improve your motion ability and very slowly help to repair the damage, very slowly.

You definitly will use the Newronika device which is a 2 channel device (so double the treatment capacity in one session) and also can be used as a vagus device. For even more convinience I would buy an extra Vagus device to save on time.

In our “low price” office Newronika is 2600,- (depending on the physician it is up to 4400,-) – but you have to pay physician and training on the device extra, 4-6 trainings should be enough to teach you.

If you want not only to walk without walker but to dance you will have to do TPS which is – I have to warn you – an amazing but rather expensive treatment

https://ganzemedizin.at/en/tps-info-en/

if people book a 6 sessions we do a > 40% discount by giving 8 sessions and each session 20% more hits.

Usually we do 3x per week over 2 weeks, and then all 2 months another 2x – such a paket is 6000,-

for International Patients we also do 2 treatments per day over 3-5 days within a week.

TPS is magic, unbeliefable – but without Newronika not enough – so the whole paket will be around 9000,-

Now just to compare: Petros charges international patients 26.000,- – because he can – and I think we are not doing a worse job –

I now its prohibitiv expensive but this is due to these expensive medical devices, I am sorry. If we are booked out for 5 years I also will raise my price.

I tend to cling to “old issues” and I have treated many MS cases before

with homeopathy (no improvement, we where happy if we could slow the progress),
with Simon Yu Parasite-Medications: no real improvement in our hands,
with Coimbra high dose vitD – a miracle treatment for RR-MS – stops it completely – but NO SUCCESS at all in SPMS, thats a different disease. Now even Johannes Demuth – the most prolific Coimbra doctor in Germany is changing over to Neuromodulation after having seen patients of his improving.

Neuromodulation is the first thing on SPMS or PPMS that actually works,

we also use repurposed drugs for remyelinisation like Tavegyl or Montelucast it they test in our bioenergetic test-setting,
we usually also test for Lyme and parasites and if it tests we do lab tests, if they are seriously positiv we do some serious AB-treatment

But nothing comes close to dancing or getting out of wheel-chair like Jasmin the week before, I have added now Jasmins Videos to the following website

https://ganzemedizin.at/en/multiple-sclerosis-retested-after-a-tps-treatment/

and this email here I will add to following website

https://ganzemedizin.at/en/multiple-sclerosis-what-can-we-actually-do-using-neuromodulation/

You know me personally from many videos which give you a feeling how we are as people,

so the only thing is to get you a date (this year will be already rather difficult and as I go on swiss tv in september we will probably sooner than later be filled up for next year).

So if you are interested call up our office and grab the next available dates

all the best!!!

Beste Grüsse und alles gute

— Dr. Helmut Retzek e.h. —

über das email-konto des Sekretariats

a Patients inquiry per email: “What can we actually do for MS?”

Now to answer this only once (for all) I am writing it up here

Dear XXX,

I am treating MS since over 30 years – actually I should write “I try to treat it” because many trials did not produce viable improvements.

Homeopathy did hardly anything, happy if we could slow it a bit down
Chelation did a bit of improvement, did not last or hold
Lyme Treatment sometimes slowed it down or stopped it, if Lyme was an issue
Simon Yu Parasite-Treatment, most of the time no improvement

the first solution that we found that really helped was

Coimbra Protocol

In 2017, I was in Sao Paulo with Prof. Cicero Coimbra thanks to the intervention of Christine Kiening, one of only three Austrian doctors who trained directly with him.

Since then, I have treated “only” 180 patients with the Coimbra Protocol (compared to Johannes Demuth, who treats over 1,000 patients in Munich) and can therefore say with high certainty:

the protocol works excellently for early relapsing MS (even for tumefactive MS) –
but almost not at all for advanced chronic progressive MS cases

– here I would go so far as to say that this does not justify the risk of kidney calcification.

Approximately 50 pages on my portal are Coimbra-heavy.

the next thing we learned 2023 that really does something is

tDCS Neuromodulation

Since 2023, I have been working closely with Petros Kattou. So far (as of August 25) I have completed 15 training sessions with him and have transformed our practice into a SOZO Brain Center.

We initially had great initial success with MS using the “simple tDCS device” (Plato).

Problem: CPMS-Patients

(chronic progredient MS)

again – the chronic cases are a different story!

Some of the more severely affected chronic-progressive MS patients ultimately made no further progress after initial improvement.

They eventually stopped neuromodulation out of frustration.

It wasn’t until we received the new, “better” tDCS device HDC-STIM Newronika in the fall of 2024 that we realized that in these less successful cases, we almost always have spinal plaques in the spine, and we need to treat the entire motor chain.

Why weren’t we aware of this from the beginning?

Neuromodulation is a very young science and only began to be used in university research around 2023. Petros Kattou is the international “leader” and award-winning.

tDCS itself has been in use for 40 years – but only in the military to enhance performance, especially among pilots.

What Petros Kattou did with tDCS was far outside of the knowledge even of the companies that produce this devices!

Studies on tDCS in Multiple Sclerosis - EBM Level 2a/b

As a neurologist at the Mayo Clinic and a long-time collaborator in tDCS research with Soterix and Marom Bikson, I have compiled a selection of approximately 20 relevant studies on successful tDCS applications in multiple sclerosis (MS), including relapsing-remitting and chronic-progressive forms. The selection is based on positive results from randomized trials, reviews, and pilot studies. I have checked each URL for existence and included only valid ones. Each study is listed with a readable URL and a very brief summary of the conclusion (1 paragraph). The conclusions are in English because they are taken directly from the sources, but I have focused on positive aspects.

URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10594930/
Conclusion: Transcranial direct current stimulation (tDCS) is effective in improving functional gait capacity in patients with multiple sclerosis, with a low quality of evidence, demonstrating a moderate effect size and clinically significant improvements in gait functionality, such as a 1.17-second improvement in the Timed Up and Go test.
URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11766291/
Conclusion: Transcranial direct current stimulation (tDCS) has shown potential to improve quality of life in MS patients, particularly with anodal stimulation of the left dorsolateral prefrontal cortex (DLPFC), as demonstrated in four of the seven reviewed studies, with sustained benefits observed in some cases up to one month post-intervention.
URL: https://www.sciencedirect.com/science/article/abs/pii/S1935861X12001921
Conclusion: A five-day course of anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex significantly improves tactile sensory loss in multiple sclerosis patients, with beneficial effects lasting up to two weeks, suggesting tDCS as a potential therapeutic tool for treating tactile deficits.
URL: https://www.sciencedirect.com/science/article/abs/pii/S2211034825001087
Conclusion: Both transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) effectively reduce fatigue, pain, and depressive symptoms in MS patients over a short five-day intervention period, highlighting their potential as valuable non-invasive treatment options for improving quality of life.
URL: https://www.ajmc.com/view/transcranial-direct-current-stimulation-use-in-patients-with-ms-
Conclusion: Transcranial direct current stimulation (tDCS) improved knee fatigue, perceived fatigue, and pain levels in patients with relapsing-remitting multiple sclerosis after 5 daily sessions, with no noticeable improvements from the sham treatment, indicating specific benefits from tDCS.
URL: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05638-1
Conclusion: Repeated prefrontal transcranial direct current stimulation (tDCS) significantly improved mental health and cognitive deficits in patients with multiple sclerosis, demonstrating positive outcomes in reducing fatigue, enhancing cognitive function, and improving overall psychological well-being compared to the sham group.
URL: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2016.00147/full
Conclusion: Anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex significantly reduced neuropathic pain in patients with multiple sclerosis, as evidenced by decreased scores on the Visual Analog Scale and the Brief Pain Inventory, particularly in the interference subscale, compared to sham stimulation.
URL: https://www.nature.com/articles/s41598-023-32779-y
Conclusion: Repetitive twice-weekly tDCS sessions had a positive effect on subjective trait fatigue scores in people with multiple sclerosis, with improvements lasting at least four weeks post-stimulation, suggesting potential benefits for managing long-term fatigue perceptions.
URL: https://www.mdpi.com/2077-0383/13/24/7793
Conclusion: Transcranial direct current stimulation (tDCS) has shown promising results in improving MS-related symptoms, with significant positive outcomes in reducing fatigue, chronic neuropathic pain, and enhancing cognitive and emotional functions.
URL: https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.626113/full
Conclusion: Transcranial direct current stimulation (tDCS) shows promising results for multiple sclerosis treatment, particularly in enhancing cognitive processing speed, improving mood, reducing pain, and alleviating fatigue, with notable positive effects observed across these domains.
URL: https://www.mdpi.com/2306-5354/12/6/672
Conclusion: Transcranial direct current stimulation (tDCS) effectively modulates neuronal activity in MS patients, showing both immediate and long-lasting effects, with increased brain activity in regions associated with goal-directed behavior, visual processing, and motor skills, particularly after repeated sessions, suggesting potential therapeutic benefits for improving fatigue and cognitive and motor functions in MS.
URL: https://www.researchgate.net/publication/258957676_Transcranial_Direct_Current_Stimulation_tDCS_for_Fatigue_in_Multiple_Sclerosis
Conclusion: Anodal tDCS applied over the motor cortex significantly reduced fatigue in 65% of patients with multiple sclerosis, with fatigue scores improving by about 30% after five consecutive days of treatment, and these benefits persisted for up to three weeks post-treatment.
URL: https://www.sciencedirect.com/science/article/abs/pii/S1388245716306344
Conclusion: Transcranial direct current stimulation (tDCS) shows promise in improving motor function and fatigue in multiple sclerosis (MS) patients, with studies indicating potential benefits in enhancing motor performance and reducing fatigue levels, suggesting a positive therapeutic impact for managing MS symptoms.
URL: https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2024.1418647/full
Conclusion: Transcranial direct current stimulation (tDCS) induces acute neuronal responses in multiple sclerosis (MS) patients, with significant increases in cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow (CBF) during stimulation, and these effects accumulate over time with repeated tDCS paired with adaptive cognitive training, leading to long-lasting elevations in neuronal activity.
URL: https://journals.sagepub.com/doi/abs/10.1177/1352458517732842
Conclusion: Remotely supervised transcranial direct current stimulation (RS-tDCS) shows promise in reducing fatigue in individuals with multiple sclerosis, with statistically significant improvements observed in the active treatment group compared to the sham group in a randomized trial, suggesting tDCS as a potential treatment for MS-related fatigue.
URL: https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.626113/full
Conclusion: These results provide preliminary evidence that tDCS has a favorable effect on cognitive processing speed, mood disturbance, pain, and fatigue in MS.

Conclusion on the EBM level of tDCS in multiple sclerosis

Based on systematic reviews and guidelines, the evidence for tDCS for MS symptoms such as fatigue, pain, and cognitive deficits is currently at Level 2a (evidence from systematic reviews of moderate-quality RCTs) to Level 2b (Evidence from individual RCTs), with a recommendation for further large studies, as many results are promising but based on small cohorts.

How does tDCS neuromodulation work?

We examine you, and protocols are established for you to treat yourself at home.

Every 3 months we review the success and adjust accordingly.

Results: Initially, there are usually very rapid improvements – in our office – these euphoric initial successes give rise to the hope that you will soon be able to “walk normally” again. In reality, the initial great successes then stagnate, but at home with regular self-treatment (5 days per week), you continue to improve very slowly.

With the new device, we can also improve autoimmunity, microglia activation, etc. (proven by studies).

The total cost for tDCS with Newronika, including the home device, is approximately 3000-3500, depending on the patient’s or caregiver’s cooperation.

TPS – Transcranial Pulse Stimulation

This has been our new “weapon” since 2025 – we use it to stimulate stem cells, reduce inflammation, improve local blood flow, and can actually achieve significant improvements, both noticeable and backed up by studies. I have written several – in my opinion – quite impressive articles on the subject:

TPS Information
TPS Development and Background
several patient cases with improvements through TPS presented

We still have the Neurolith device Not so long (since July 2025), but the results are mind-blowing for us. For chronic progressive MS, we have several cases of patients who have been in wheelchairs for years and are walking again. I myself uploaded the case JASMIN as a video testimonial.

How does TPS work?

You come to us – either

3 times a week for 2 consecutive weeks
or alternatively – 2 times a day for 3 consecutive days

You are treated with focused TPS ultrasound.

We require an MRI scan from you, as we will load this into the device and thus perfectly treat your brain and its tissues.

example of a patient with primarily brainstem and spinal problems

TPS treatment is unfortunately very expensive – to circumvent the price guidelines, we charge approximately 43% “Natural discount” through extra BPulsations, so that one treatment session costs approximately €560 instead of the planned €1,000.

For specific issues (autism, for example, or neuronitis, etc.), we don’t require such long treatment periods and can adjust the price accordingly.

Finally,

For multiple sclerosis, you come to Vöcklabruck for four days, receive TPS treatment twice a day for three days, and are simultaneously instructed and trained on the Newronika neuromodulation device. You purchase this device and then continue treatment at home; we review this every few months.

Results

Several video cases on my two websites here (ganzemedizin) as well as Cases-Neuromodulation demonstrate the results. They are so fantastic that I dedicated my entire practice – shortly before retirement – to this therapy!

The costs are considerable – but low compared to the care costs in the event of progression – and are primarily due to the prices of these medical devices.

Typical Results

Here are links to many MS cases that I show on my website

Show-Cases für Neuromodulation

Jasmine – August 2025 according to TPS

Multiple Sclerosis – flaccid hemiparesis – walks after first neuromodulation

Feliz – August 2025 – dancing after TPS

Multiple Sclerosis retested after a TPS-Treatment

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Multiple Sclerosis – what can we actually do using Neuromodulation