interstitial cystitis – chronic irritable bladder

interstitial cystitis – chronic irritable bladder

update 2024 – Interstitial cystitis is an MCAS

Mast cell activation syndrome.

Thanks to my research back in 2020 (see below) we found this out and have since completely cured several cases.

Treatment is actually quite simple: ketotifen and a low-histamine diet as well as everything that is good for MCAS (brainstem stimulation, tDCS, SPIKE detox ….).

Claudia will write to me in November 2024

Claudia is a German HP who has actually found out what is behind this disease:

I supplement keto with Atarax, an old and proven antihistamine. Few side effects!!! Calms and helps you fall asleep! Histamine makes you restless and disturbs your sleep, which in turn causes mast cell stimulation. With Atarax, it is easier to calm down in general. 12.5 mg is usually enough.

I have some ICs in women after COVID (illness, not vaccination)
Goes away after 3-4 months with good treatment
Do you see that too?

My illness started in January 2020

At the end of 2019, I had a bad cough. There were a lot of pneumonia cases here in Corfu at the time. One person died from it. I now assume that I had COVID at the time.

Interesting because Covid had not yet been officially discovered at the time

I no longer have any of the IC. What remains is a slight histamine intolerance
I occasionally take Atarax or a week of keto.

Fits👍

Trigger

unclear, varied

Associations

more than 70% of patients have fibromyalgia, ulcerative colitis, Crohn’s disease – so there is definitely an overarching mechanism.

Summary of my research

I have read about 120 studies on the subject of interstitial cystitis. It was extremely difficult, as the answer was always the same: “unclear cause, terrible, tormenting symptoms, hardly any improvement” …., many attempts at therapy that only partially worked for a limited number of patients.

Ultimately, I have come to the conclusion that interstitial cystitis is caused by

1. a disruption of the permeability of the bladder mucosa, so that urine contents can pass through the mucosa
2. mast cell overactivity with histamine release, often triggered by stimuli from the urine.

In addition to trying to improve the mucosal integrity (heparin instillations, ….. –> MSM (sulfur) + mini-amount of ascorbic acid + magnesium + horsetail / willowherb tea

it is mainly about stabilizing the mast cells and the To reduce histamine.

Here, Ketotifen has proven particularly helpful, and there are also homeopathic tricks to reduce the effect of histamine.

I suspect that the majority of the mast cell activation syndrome comes from the intestine in the sense of leaky gut and lectin infiltration. A dietary modification according to Steven Gundry may be helpful here.

The German HP Claudia Fröhlich (just moved to Corfu) has had particularly good success in treating this terribly tormenting disorder!