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HomeresearchEBV and Breast Cancer - connection exists
Das Epstein-Barr-Virus, hier in Leukämiezellen grün angefärbt (c) CDC/Dr. Paul M. Feorino
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EBV and Breast Cancer – connection exists

HeliR
By HeliR

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23
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A patient asks me whether EBV might also be involved in her breast cancer.

I tell her my suspicion that HPV (the wart virus), in particular, could play a significant role here because it inactivates p53 (the cell’s police gene), which ensures that “degenerating cells” eliminate themselves (apoptosis).

As I say this, I think to myself that it’s possible that EBV, as HIV’s little brother, could play a role through immune dysregulation.

Then I think to myself, why waste so much time discussing this? We can quickly research it. A few minutes later, I’m totally astonished because, based on the studies, it actually appears that EBV does indeed infect breast cancer tissue, transforming it into a premalignant tissue, and can significantly influence the onset and overall course of breast cancer.

This makes EBV a possible target for holistic, adjunctive treatment for breast cancer.

Treatment of EBV - many things tried, not many worked well

We have been using low-dose valacyclovir for 2-3 years now, because all other methods have been too complex for us in our specific practice setting (Murdannia, microimmunotherapy, high-dose VitC infusions, ozone therapy, haemolaser) – although in urgent cases, we naturally use all of these, and ozone + haemolaser photodynamic therapy (riboflavin + blue laser) is the most effective – but this requires patients to visit us at least 10 times, which many are unwilling to do. The tablets can be easily taken at home and are covered by health insurance. Almost always, not only EBV but also HSV and HHV are present, which are treated with Vala.

I’ve researched many different articles about EBV here.

https://ganzemedizin.at/tag/ebv/

If you, dear colleague, disagree and know of an effective, simple, and cost-effective treatment, please contact me or comment below!

about EBV as the 'little brother of HIV'

EBV as the “little brother” of HIV

The Epstein-Barr virus (EBV) is often referred to as the “little brother” of the human immunodeficiency virus (HIV), as both viruses attack the immune system but affect different mechanisms and cell types. While HIV primarily invades T cells and destroys them during the course of infection, EBV preferentially establishes itself in B cells and lymph nodes.

EBV is capable of establishing a latent infection in B cells, suppressing the immune system by disrupting the normal immune response. It induces chronic immune activation, which has been associated with the development of autoimmune diseases such as systemic lupus erythematosus and other immunological disorders. EBV can also exert a debilitating effect on the immune response by impairing the function of T cells and natural killer (NK) cells.

Although EBV does not directly attack T cells like HIV, the prolonged, debilitating immune response induced by EBV contributes to an increased risk of infections and autoimmune diseases. This chronic immune disruption can destabilize the immune system over the long term, leading to a type of “immune exhaustion” similar to the immunopathology affected by HIV, but via different cellular mechanisms.

Overall, EBV has a subtle but profound effect on the immune system, similar to HIV in its form of weakening and autoimmunity, but affecting other cell types and immune pathways.

 

Study searches on EBV x breast cancer = 120,000 entries on Scholar

 

1. Epstein-Barr virus in breast carcinomas and in triple-negative cases

This study demonstrated the presence of EBV DNA in breast carcinomas and found that EBV was associated with aggressive features and poorer overall survival.

Study 2023

2. Epstein-Barr Virus Infection of Breast Epithelial Cells Promotes Tumor Formation

Research shows that EBV infections can promote tumor formation in breast epithelial cells, but not in breast cancer cells. Study 2016 | fullTextPDF

 

3. Role of Epstein-Barr Virus in Breast Cancer: Correlation with Clinical Features

This study found that EBV was correlated with HER-2 status and histological grade in breast cancer samples. Study 2024

 

4. Epstein-Barr Virus Infection and Increased Risk of Sporadic Breast Cancer

An analysis of 16 studies with 1,279 patients showed that EBV infections were associated with an increased risk of sporadic breast cancer.

Study 2020

 

 

5. Detection of Epstein-Barr Virus in Invasive Breast Cancer Cases

This study documented the Detection of the EBV genome in a large number of breast cancer cases and found that the virus was restricted to tumor cells. 1999 study

These studies indicate a possible link between EBV and breast cancer, although the exact role of the virus in carcinogenesis has not been clarified, but I haven’t had the time to do so. Perhaps one of our valued readers can do this?

 

Cover image

The Epstein-Barr virus, shown here in leukemia cells stained green (c) CDC/Dr. Paul M. Feorino

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